We are delighted that our paper has just been accepted for publication in PCCP

Delighted that our paper “Unusual Mechanism of Aziridine Biosynthesis Catalysed by an αKGdependent Non-heme Enzyme TqaL” has just been accepted for publication in PCCP!

Aziridine is an essential building block in the synthesis of valuable pharmaceuticals, including Mitomycin C. However, synthesizing aziridine poses significant challenges due to the substantial ring strain in its three-membered structure. In this research, we elucidated the detailed reaction mechanism of aziridine biosynthesis catalyzed by the non-heme enzyme TqaL, an α-KG dependent iron-containing oxygenase. Our findings present the structural basis for engineering the enzyme for the biosynthesis of biologically active aziridine-containing natural products.

View article: DOI: 10.1039/D4CP03708A.